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Table of Contents | |
- Pruritis--generalized itching of the skin
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| Schweiz Med Wochenschr 1995 Nov 18;125(46):2244-50 |
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[Pruritus--also a challenge in internal medicine].
[Article in German]
Brunner W
Medizinische Klinik, Kantonsspital Chur.
Generalized or localized itch without primary skin manifestations may be the
presenting symptom of serious internal diseases. Five characteristic cases
of pruritus are discussed: Hodgkin's disease, primary sclerosing cholangitis,
polycythemia vera, iron deficiency (with pica), and uremia. Other important
causes must be considered; all forms of cholestasis, including primary
biliary cirrhosis, drug-induced, pregnancy-related, and extrahepatic
cholestasis; other hematologic and malignant disorders such as non-Hodgkin's
lymphoma, leukemia, multiple myeloma, solid tumors, and myelodysplastic
syndromes; metabolic and endocrine diseases, most notably diabetes mellitus,
hyperthyroidism, hypothyroidism, and carcinoid syndrome; focal neurologic
diseases such as brain tumors, cerebral infarctions and multiple sclerosis;
adverse drug reactions without rash; infectious diseases, especially
parasitic and HIV infections. A diagnostic laboratory screening for pruritus
of undetermined origin is suggested.
PMID: 8525344, UI: 96091969
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