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SELENIUM AND COPPER INTERACTIONS Low
selenium may contribute to high hepatic copper levels: Title The LEC rat possesses reduced hepatic selenium, contributing to the severity of spontaneous hepatitis and sensitivity to carcinogenesis. Author Downey JS; Bingle CD; Cottrell S; Ward N; Churchman D; Dobrota M; Powell CJ Address Department of Toxicology, St. Bartholomew's & the Royal London School of Medicine and Dentistry, United Kingdom. Source Biochem Biophys Res Commun, 244(2):463-7 1998 Mar 17 Abstract The hepatic concentrations of copper, zinc, magnesium, calcium, and selenium were measured in LEC rats, which develop a spontaneous form of hepatitis at 3-4 months of age, and compared to trace metal concentrations in the LEA rat, its asymptomatic congenic strain. Consistent with results found by other groups, copper was found to accumulate within the liver of LEC rats to levels more than 50 times those measured in LEA rats. In addition, liver selenium concentration in LEC rats was found to be around 50% of that in LEA rats. The enzyme activity, and RNA for the selenium dependent enzyme, glutathione peroxidase, was also found to be reduced in LEC rat liver. These results indicate that hepatic selenium in the LEC rat is depleted and that, as a result of this, the capacity to protect cells from copper-induced free-radical damage is reduced. “Selenium
bullets were associated with a reduced copper
uptake when selenium bullets and oxidised copper particles were given together.”
selenium
and copper interactions in cattle.doc “Although
a high concentration of copper
(200 mg/kg) in the diet did not alter the percentage absorption and total-body
retention of doses of 75SeO3(2)- by rats, after such treatment tissue 75Se
distribution was changed and was lower total selenium in some tissues. After copper treatment (200
mg/kg diet) GSH-Px activity of liver, testis, kidney and whole blood was also
lower.” selenium
distribution affected by copper.doc “The
most striking result is a marked interaction between silver and methyl mercury:
when Ag is present in the water jointly with MeHg, it exerts a negative action
on Hg bioaccumulation in the fish, at the whole organism level. Bioaccumulation
of silver is also significantly influenced by the presence of Zn, Cu, and Se in
the water, the action of these three elements producing an increase in the
amounts of Ag in the organisms.” selenium.copper.silver.mercury
interactions.doc “In
animals exposed to Se an increase in the copper
concentration was observed in blood and brain; zinc was increased in the blood,
heart, brain, and stomach, but decreased in the kidneys.”
selenium
effects on copper and zinc.doc
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