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COLLAGEN DISEASES

Many diseases are caused by collagen deficiency or are caused by deficiencies that also cause collagen deficiency. On this page I am collecting studies related to collagen.

The following study suggests that the amino acid lysine is essential for collagen production.

Ciba Found Symp 1980;79:163-82

Copper and the synthesis of elastin and collagen.

Harris ED, Rayton JK, Balthrop JE, DiSilvestro RA, Garcia-de-Quevedo M.

Copper's role in connective tissue is linked to the enzyme lysyl oxidase. From a biochemical perspective, copper is a cofactor for the enzyme and a determinant of its activity in connective tissues. Lysyl oxidase catalyses a post-translational oxidation of certain lysine and hydroxylysine residues. The peptidyl aldehydes so formed become active centres for the formation of cross-links in collagen and elastin. Less well understood is how copper controls the steady-state activity of lysyl oxidase; the enzyme fails in copper deficiency. Giving copper to a deprived animal increases lysyl oxidase activity in aortic tissue. Such activation in vivo appears to require caeruloplasmin. Suspending aortic tissue in a copper-enriched growth medium also activates lysyl oxidase provided that tissue structure is kept intact. Activation in vitro occurs with the binding of copper to a large-molecular-weight component, presumably the enzyme. Binding will not occur if protein synthesis is blocked. These studies clearly show that the synthesis of mature elastin and collagen can be controlled by the availability of copper. They further suggest that transport of copper to aortic tissue and its engagement to lysyl oxidase are linked to the synthesis or lysyl oxidase, an extracellular carrier, or both.

PMID: 6110524 [PubMed - indexed for MEDLINE]