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CALCIUM
 
Rough file:

"In this paper the authors studied the effects of thyroid hormones and their structural analogues on the mitochondrial calcium transport activities. The thyroid hormones, 3,5,3' L-triiodothyronine (LT3) and 3,5,3'5' L-tetraiodothyronine (LT4) at physiological intracellular concentrations between 7.2 and 9 nM, decouple total Ca++ transport, as well as inhibit the passive transport of Ca++, either due to oxidation of pyruvate, malate or succinate or after inhibition with rotenone. The optical isomers 3,5,3' D-triiodothyronine (DT3) and 3,5,3',5' D-tetraiodothyronine (DT4) are less effective at all the used concentrations. Furthermore the structural analogues 3,3',5' L-triiodothyronine (LrT3), 3,5-dicloro, 3',5' L-diiodothyronine (LDiClT2) and 3,5 L-diiodothyronine (LT2) furnished even less effects on the same activities. The effect of the thyroid hormones and of their structural analogues has revealed that the mitochondrial calcium transport may be influenced both by a stereospecific interaction between hormones and protein ligands and by a lipophilic chaotropic action on the mitochondrial membranes lipids. In this context it is interesting to consider that both thyroid hormones and Ca++ transport activity are interacting with the energetic metabolism by means of phosphorylation and substrate oxidation mechanism." calcium--effects on transport by T3.doc

Title
Calcium is the first messenger for the action of thyroid hormone at the level of the plasma membrane: first evidence for an acute effect of thyroid hormone on calcium uptake in the heart.
Author
Segal J
Address
Hubert H. Humphrey Center for Experimental Medicine and Cancer Research, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Source
Endocrinology, 126(5):2693-702 1990 May
Abstract

The thyroid hormone T3 produced a very rapid and transient increase in 45calcium uptake by freshly isolated rat heart slices, which was seen already 15 sec after the addition of the hormone, reached a maximum at 30 sec, and then progressively declined and returned to control values after 10 min. This effect of T3 was independent of extracellular calcium, concentration related (evident at a physiological concentration of 10 pM, reached maximum of about 75% above control at 1 nM, and was smaller at greater concentrations), and thyroid hormone specific, as judged from the order of potency of several thyroid hormone analogs: L-T3 greater than L-T4 greater than or equal to D-T3 greater than 3'-isopropyl-3,5-L-diiodothyronine greater than D-T4 greater than 3,5-L-diiodothyronine greater than r-L-T3 greater than D,L-thyronine. The inorganic calcium channel blockers La3+, Cd2+, and Mn2+ inhibited, in a concentration-related fashion, basal and T3-induced increases in 45Ca uptake in the cardiac slices. The organic calcium channel blockers verapamil, nifedipine, and diltiazem were without effect, indicating that in the quiescent cardiac slice the effect of T3 on 45Ca uptake is independent of sarcolemmal depolarization. Additional studies demonstrated that the stimulatory effect of T3 on 2-deoxyglucose uptake by the cardiac slices required extracellular calcium and was inhibited by the calcium channel blockers La3+, Cd2+, and Mn2+. The present study provides conclusive evidence for two central issues: that calcium is the first messenger for the prompt, plasma membrane-mediated action of thyroid hormone to increase cellular sugar uptake, and that thyroid hormone produces an acute increase in calcium uptake by the heart, an effect that is demonstrable at physiological concentrations and is thyroid hormone specific and, therefore, points to a physiological relevance for this action.

 

  1. Expression of receptors to extracellular calcium enables parafollicular cells of the thyroid gland (PF cells) to release calcitonin (CT) and serotonin (5-HT) in response to increased external Ca2+. Recently, a calcium-sensing receptor (CaR), similar to the G protein-coupled receptor for external Ca2+ cloned from parathyroid gland, was shown to be expressed in PF cells. Using a highly purified preparation of sheep PF cells, we have examined the electrical and biochemical processes coupling CaR activation to hormone release. 2. Whole-cell recordings in the permeabilized-patch configuration show that elevated extracellular Ca2+ concentration ([Ca2+]0) depolarizes these cells and induces oscillations in membrane potential. In voltage clamp, high [Ca2+]0 activates a cation conductance that underlies the depolarization. This conductance is cation selective, with a reversal potential near -25 mV indicating poor ion selectivity. 3. The CaR expressed in these cells is activated by other multivalent cations with a rank order potency of Gd3+ > Ba2+ > Ca2+ > > Mg2+. The insensitivity of these cells to high external Mg2+ contrasts with the reported sensitivity of the cloned CaR from parathyroid. 4. Elevation of [Ca2+]0 also stimulates increases in intracellular Ca2+ concentration ([Ca2+]i) and this effect is largely inhibited by the Ca2+ channel blocker nimodipine, indicating that L-type voltage-gated Ca2+ channels contribute to the response to elevated [Ca2+]0. 5. Elevated [Ca2+]0 induces an inward current under conditions where the only permeant external cation is Ca2+, indicating that influx via the cation conductance is another source of the increases in [Ca2+]i. 6. Extracellular Ca2+ stimulates 5-HT release with an EC50 of 1.5 mM. Nimodipine blocks 90% of the Ca2+0-induced 5-HT release, while other inhibitors of voltage-gated calcium channels had no effect. These data support an important role for L-type Ca2+ channels in CaR-induced hormone secretion. Although earlier studies indicate that high [Ca2+]0 induces release of Ca2+ from intracellular stores, thapsigargin-induced depletion of these stores did not affect secretion from these cells, indicating that Ca2+ influx is necessary and sufficient for the Ca2+0-induced 5-HT secretion. 7. Inhibition of protein kinase C (PKC) using chelerythrine, staurosporine, or calphostin C inhibited Ca2+0-induced 5-HT release by 50% while phorobol ester-induced 5-HT secretion was completely inhibited. Thus, PKC is an important component of the pathway linking CaR activation to hormone release. However, another as yet unknown second messenger also contributes to this pathway. 8. We tested the contribution of two different phospholipases to the CaR responses to determine the source of the PKC activator diacylglycerol (DAG). Selective inhibition of phosphatidylinositol-specific phospholipase C (PI-PLC) with U73122 had no effect on the response to elevated [Ca2+]0. However, pretreatment with D609, a selective inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC), inhibited Ca(2+)-induced 5-HT release to 50% of control indicating that phosphatidylcholine is a likely source of DAG in the response of PF cells to elevated [Ca2+] calcium receptor mediated hormone release.doc

Basal and thyrotrophin (TSH)-stimulated release of iodothyronines (triiodothyronine, T3, and thyroxine, T4) from intact chicken thyroid glands was determined in vitro. In the absence of TSH, T3 and T4 were released in measurable amounts in the incubation media. The release of both iodothyronines was directly related to the media TSH concentrations and incubation period. Lineweaver-Burke analysis revealed that the Vmax for T3 was 99.4 pg/gland, with an apparent Km of 17.8 mU TSH, and that the Vmax for T4 was 323.35 ng/gland, with an apparent Km of 51.5 mU TSH, demonstrating that T4 is the major iodothyronine released by avian thyroid glands. The basal release of T4 was suppressed by the addition of a calcium chelator (ethyleneglycol-bis-(beta-aminoethylether)-N,N,N', N'-tetraacetic acid; EGTA), a calcium antagonist (cobalt chloride, CoCl2), or prostaglandin E1 (PGE1) to the incubation media. Basal T4 released was increased in the presence of a calcium agonist (lanthanum chloride, LaCl3), a calcium ionophore (A23187), dibutyryl cyclic adenosine 3'3'-monophosphate (dbcAMP), isobutylmethylxanthine (IBMX), indomethacin, magnesium chloride (MgCl2), and potassium iodide (KI). Thyrotrophin-stimulated T4 release was reduced by CoCl2, PGE1, and indomethacin but enhanced by LaCl3, MgCl2, and KI. These results demonstrate that it is possible to measure the release of thyroid hormones in an in vitro system in the chicken. Basal and stimulated iodothyronine release from the chicken thyroid gland appears to be mediated by calcium- and cAMP-dependent mechanisms.calcium antagonists inhibit T4 production.doc

Low bone mineral density (BMD) and increased bone turnover are common features of untreated hyperthyroidism in adult patients. The effect of treatment on BMD is still controversial. BMD and bone metabolism in hyperthyroid children have not been thoroughly investigated. In the present study, we measured spinal and whole body BMD by dual-energy X-ray absorptiometry in a group of 13 girls (aged 5.0-14.9 years) at diagnosis of hyperthyroidism. The bone resorption rate was assessed by urine measurement of N-terminal telopeptide of type I collagen (NTX). Hyperthyroid patients have been studied longitudinally during treatment. BMD values and NTX urine concentrations have been also determined in 155 healthy Caucasian girls (aged 2.4-24.2 years). Spinal and whole body bone density measurements were significantly lower compared with healthy controls in untreated hyperthyroid girls, after correction for differences in age and anthropometric measurements (p </= 0.033). Bone density measurements obtained after 12 and 24 months of treatment were no longer different from those of healthy girls. NTX urine levels at diagnosis of thyrotoxicosis were significantly higher than those found in healthy controls (p < 0.0001); 6 months after treatment, the urine levels did not show significant differences, and they remained stable after 12 and 24 months of therapy. Inverse correlations at diagnosis were found between serum-free thyroxine (FT4) serum levels and spinal (r = -0.42) and whole body bone density (r = -0.41); FT4 and free triiodothyronine serum levels directly correlated with the NTX concentration (r = 0.77, and r = 0.71, respectively). In conclusion, the results of the present study demonstrate that low bone density values and high bone resorption rates are found in hyperthyroid children and adolescents at diagnosis of the disease. Our data also demonstrate that antithyroid treatment is able to reduce dramatically the bone resorption and to increase significantly both spinal and total body BMD, granting physiologic conditions for the achievement of the best obtainable peak bone mass.calcium--bone mineral density increases in hyperT girls during treatment.doc

Calcium may become a dieter's best friend

From Science News, April 29, 2000

There's encouraging news for people who've been losing the battle of the bulge. Weight loss may be at hand-if that hand begins reaching for a glass of milk, slice of cheese, or dish of yogurt, all low-fat, of course.

At the Experimental Biology 2000 meeting last week in San Diego, scientists from the University of Tennessee in Knoxville reported dramatic findings from a weight-loss study in mice. How much calcium the animals consumed-and its source-greatly affected what share of their meals turned to fat.

Reanalysis of data collected earlier on women supports that finding, another scientist adds.

The Tennessee team used mice that model human patterns of obesity. The animals had been genetically engineered to express in their fat cells a gene called agouti, which normally operates in human but not mouse fat cells. This gene strongly influences whether a fat cell burns energy-containing molecules or converts them to fat.

Michael B. Zemel, who directs the university's Nutrition Institute, and his colleagues put these mice onto a low-calorie diet for 6 weeks. Their meals contained just 70 percent as much energy as the rodents would normally choose to eat. One group received a diet that was also deficient in calcium. Its calcium content, adjusting for species differences, is "almost exactly what American women are consuming," Zemel notes, "about 500 milligrams per day." That's well below the recommended daily allowance of 1,300 mg calcium.

The calorie-restricted mice lost 8 percent of their body fat and 11 percent of their weight.

Zemel's group again restricted the food but boosted calcium intake of another two groups of the mice. Each received the mouse equivalent of a human dose of 1,600 mg calcium per day. Mice getting this as a carbonate supplement lost 42 percent of their body fat and 19 percent of their weight. Those that consumed the extra calcium as nonfat dry milk-substituted for an equal amount of dietary protein-lost 60 percent of their body fat and 25 percent of their weight.

A fourth group, receiving twice as much dairy-derived calcium, showed little extra benefit, Zemel notes.

These differences occurred even though all of the low-calorie groups got the same exercise and mix of dietary fat, protein, and carbohydrates. The results show that varying dietary calcium alters the animals' metabolism, says Zemel. Among the dieting animals, core body temperatures measure of basal energy use-fell during the low-calcium diet but climbed with the high-calcium chow.

Under low-calcium conditions, the Tennessee scientists find, the agouti gene directs calcium channels to open. "That turns out to be a bad thing," Zemel says, because it activates fat synthesis while suppressing fat breakdown.

Zemel's group is now testing whether a 6-month augmentation of dietary calcium will offer similar weight-loss benefits to obese women.

"I'm impressed by this," says Robert Marcus of the Veterans Affairs Medical Center in Palo Alto, Calif., referring to the mouse data reported last week.

When endocrinologist Robert P. Heaney of Creighton University in Omaha, Neb., first learned of preliminary data by Zemel's group last year, "I thought they made sense-but I still had a degree of skepticism," he says. So, he reanalyzed data from five calcium-supplement trials he had conducted in people over the years.

"And in all five," he says, "we found a significant weight effect that we had ignored." These data, to be published soon, show that women consuming the least calcium weighed the most.

Ironically, Zemel says, among weight-conscious teens, "the first thing they jettison from their diet is dairy." This choice, he suspects, is "moving them farther from their goal, not closer." J. Raloff

The following is interesting, but I don't know the exact source.

CHAPTER SIXTEEN
CAN CALCIUM CURE CANCER?
In 1932 Otto Warburg won the Nobel Prize in Medicine for his discovery that cancer was anaerobic: cancer occurs in the absence of free oxygen. As innocuous as this discovery might seem, it is actually a startling and significant finding worthy of a Nobel Prize. What it basically means is that cancer is caused by a lack of free oxygen in the body and therefore, whatever causes this to occur is the cause of all cancers.
In chemistry, alkali solutions (pH over 7.0) tend to absorb oxygen, while acids (pH under 7.0) tend to expel oxygen. For example, a mild alkali can absorb over 100 times as much oxygen as a mild acid. Therefore, when the body becomes acidic by dropping below pH 7.0 (note: all body fluids, except for stomach and urine, are supposed to be mildly alkaline at pH 7.4), oxygen is driven out of the body thereby, according to Nobel Prize winner Otto Warburg, inducing cancer. Stomach fluids must remain acidic to digest food and urine must remain acidic to remove wastes from the body. Blood is the exception. Blood must always remain at an alkaline pH 7.4 so that it can retain its oxygen. When adequate mineral consumption is in the diet, the blood is supplied the crucial minerals required to maintain an alkaline pH of 7.4. However when insufficient mineral consumption is in the diet, the body is forced to rob Peter (other body fluids) to pay Paul (the blood). In doing so, it removes crucial minerals, such as calcium, from the saliva, spinal fluids, kidneys, liver, etc., in order to maintain the blood at pH 7.4. This causes the de- mineralized fluids and organs to become acidic and therefore anaerobic, thus inducing not only cancer, but a host of other degenerative diseases, such as heart disease, diabetes, arthritis, lupus, etc..
Everyone knows that the human body is made up of 78% water by weight, and that water is hydrogen and oxygen gases. When nitrogen gas and carbon in the form of carbon dioxide and methane gases are added, the total gas in the body by weight becomes over 95%. Almost half of the remaining 5% that makes up the human body and controls all biological functions is the mineral calcium,
No other mineral is capable of performing as many biological functions as is calcium. Calcium is involved in almost every biological function. This amazing mineral provides the electrical energy for the heart to beat and for all muscle movement. It is the calcium ion that is responsible for feeding every cell. It does this by latching on to seven nutrient molecules and one water molecule and pulls them through the nutrient channel. It then detaches its load and returns to repeat the process. Another important biological 'ob for calcium is DNA replication, which is crucial for maintaining youth and a healthy body. Calcium ions are indispensable for DNA replication (Calcium in the Action of Growth Factors, W.H. Moolenaar, L.K. Defize, and S.W. Delaat, 1986 Calcium and the Cell, Wiley) which is the basis for all body repair. It can only occur "on a substrate of calcium" (The Role of Calcium in Biological Systems, Albert Lehniger, Professor of Medical Science, John Hopkins University, Volume 1, CRC Press). Thus, low calcium means low body repair and premature aging. As important as all these and hundreds of other biological functions of calcium are to human health, none is more important than the job of pH control. Calcium to acid, is like. water to a fire. Calcium quickly destroys oxygen robbing acid in the body fluids. Thus, the more calcium, the more oxygen, and therefore, the less cancer and other degenerative disease.
This information then begs the question, "How much calcium is necessary ?" Biologically, the human body requires 800 milligrams daily, but since calcium is extremely difficult for the body to absorb, the question then becomes "How much calcium do we have to consume to absorb 800 milligrams ?" As was discussed in previous chapters, the cultures around the world that consume "Milk of the Mountains", the Hunzas in Pakistan, the Armenians, Azerbaijans and Georgians in Russia, the Vilcabamba Indians in Equador, the Titicacas Indians in Peru, the Bamas in China and the 'lligrams of Tibetans, all actually ingest an astounding 100,000 milligrams of calcium each day, and all have no cancer, diabetes, heart disease, arthritis, and all other degenerative diseases as well as mental disorders. This proves that you cannot consume too much calcium and that excess calcium must readily pass harmlessly out of the body through the urine. The only long living culture that does not consume the "milk of the Mountains' is the Okinawans who consume large quantities of "Milk of the Oceans"
Millions of Okinawans live in the southern coral islands of Japan with the average life expectancy of 105 years, while mainland Japan is just 77 years. The Okinawans live on islands made of coral reefs which are mainly calcium. The Okinawans discovered over 500 years ago that feeding coral sand that is produced from the weathering of the reefs to the chickens and cows results in twice as many eggs and twice as much milk. They also found that when the coral sand is used as a fertilizer, crops increase. by as much as three fold. When they finally, 500 years ago, began to consume the coral sand themselves, all of the under utilized doctors were forced to leave the islands. This was known in Japanese history as the Japanese Exodus.
The early European explorers discovered their secret and hauled shiploads of the calcium rich coral sands back to Europe. In Madrid Spain, the historic monument of the world's first drugstore contains rows of shelves labeled "coral calcium from Okinawa Japan". Today millions of people all over the world consume coral calcium, and as a result, there are millions of medical testimonials.
The phenomenon of preventing and reversing degenerative disease through the consumption of large amounts of mineral and vitamins did not go unnoticed by men of medicine. Hundreds of years ago European doctors were prescribing coral calcium and other nutrients to their patients.
L the 1950s, Dr. Carl Reich M.D. discovered that his patients were able to "cure themselves" of almost all degenerative diseases by consuming several times the RDA of calcium, magnesium, vitamin-D and other nutrients. Dr. Reich was the first North American doctor to prescribe "mega doses" of minerals and vitamins to his patients and is considered by many to be the father of preventive medicine. By the 1980s Dr. Reich had cured thousands, but lost his license for explaining that the consumption of mineral nutrients, such as calcium, could prevent cancer and a host of other diseases. This concept was considered "too simple" to accept by the medical wisdom of the day. However, by the late 1990s, other medical men of wisdom were also discovering that calcium supplements could indeed reverse cancer. In the October 13, 1998 issue of the New York Times wrote an article appeared entitled "Calcium Takes Its Place As a Superstar of Nutrients P" 'in which it reports that a study published in the Journal of the American Medical Association reported that "increasing calcium induced normal development of the epithelia cells and might also prevent cancer in such organs as the breast, prostate and pancreas". It also reported that the American Journal of Clinical Nutrition published "virtually no major organ system escapes calcium's influence" and that a research team from the University of Southern California found "adding calcium to the diet lowered the blood pressure in I IO black teenagers".
The January 14, 1999 issue of the Phoenix Republic wrote in an article entitled "Calcium Reduces Tumors" that the New England Journal of Medicine reported "adding calcium to the diet can keep you from getting tumors in your large intestine". Then the February, 1999 issue of the Readers Digest wrote in an article entitled "7he 'Superstar' Nutrient" that the Journal of the American Medical Association published "when the participants consumption reached 1500 milligrams of calcium a day, cell growth in the colon improved toward normal (this means that the cancer was re- versed)". The Digest also reported that the Metabolic Bone Center at St. Lukes Hospital believes that "a chronic deficiency of calcium is largely responsible for premenstrual syndrome (PMS)" and that "a lot of women are avoiding the sun and their vitamin-D levels may be very low". In he same article, the Digest reported that "in 1997 the large federally financed trial found that a diet containing 1200 milligrams of calcium significantly lowered blood pressure in adults". Then the May 3. 1999 edition of US World News Report wrote in an article entitled -Calcium's Powerful Mysterious Ways" that, "Researchers are increasingly finding that the humble mineral calcium plays a major role in warding off major illnesses from high blood pressure to colon cancer' and that "You name the disease and calcium is beginning to have a place there" (David McCarron, a nephrologist at Oregon Health Sciences University).
Unfortunately, most doctors have not heard the news that their own journals, major newspapers and magazines are reporting that natural supplements, especially calcium, can cure and prevent disease.
The scientific evidence that calcium is the key to good and long health is overwhelming. Just 20 years ago, any doctor making the claim that calcium supplements could cure cancer would loose his license. Dr. Carl Reich lost his license for making this claim which the medical authorities of the day branded as "too simplistic". Yet today, the doctor's own Journals: The New England Journal of Medicine, The Journal of the American Medical Association, and the American Journal of Clinical Nutrition are all making the claim that calcium supplements can reverse cancer and that virtually no organ escapes calcium's influence. These journals have been quoted in our popular and respectable newspapers and magazines. We have come a long way, and still have a long way to go. At present, it is almost impossible to find a doctor who is aware of these scientific findings. Therefore, we must get the doctors to read their own Journals and then do an almost impossible task, get the American Medical Association and the Food and Drug Administration to do their jobs and endorse these scientific findings. When this finally occurs, over 90% of disease will be eradicated thereby eliminating massive pain and suffering, and we will be well on our way to curing America.
One does not have to be a rocket scientist to read simple articles in reputable newspapers, magazines quoting the doctor's own journals that are all saying that disease can be cured by diet. Also one can simply look at the millions of people around the world that never get sick and say, "Lets do what they do !"Unfortunately, all of their milk of the mountains is consumed as fast as it is produced. However, the Japanese could cure the world with their "milk of the oceans" known as coral calcium, the calcium factor of good health.
CHAPTER SEVENTEEN
QUESTIONS AND ANSWERS
The most frequent question asked the author is, "What do you do ?" The response always begins with, "I have not taken a pill in over 30 years. " Psychologically, taking pills is synonymous with taking drugs. Also, many people have difficulty swallowing pills. For most, many of the pills remain intact as they pass through the intestine undigested. The obvious solution is to do what the author does. First, the author puts all of the non liquid nutrient pills and capsules into a blender to make a pulverized blend. He then uses a flour sifter to remove the broken up oversized capsule containers. The author takes 24 pills and capsules each day, and he has found that when pulverized, the blend fills a heaping teaspoon. Thus the author pulverizes a three month portion and puts it into a large bottle labeled "Hunza Powder", and then takes a heaping spoonful each day. Secondly, the nutrient blend should be taken at meal times, as for the elderly, this is the only time that they have sufficient acid in their stomachs to digest food. Thirdly, one glass of milk or one glass of apple juice should be taken with each meal so that the lactates or malates will keep the digested nutrients ionized even as they pass through the alkali duodenum, thereby allowing for greater absorption. Also, the consumption of fruits and vegetables with meals provides anions which enhance the absorption of nutrients.
The second most frequent question asked is, "which are the 24 pills that you take The answer is 3 coral calcium (1.5 grams), 2 vitamin-D (5000 IU each), 6 multivitamins (one-a-day), 6 multi-minerals (containing 60 trace minerals), 3 calcium (citrate), I magnesium citrate, 2 vitamin-C (60 mg each), I vitamin-E (500mg), and 10 milligrams cesium chloride. The result is Hunza Powder. The author takes a heaping teaspoon each day, usually mixed in a fruit slush or a banana shake.
The next most asked question is 'What do I have to do to cure....... ?" The answer is that the body can cure itself of all disease if given the nutrients it needs. To begin with, the DNA which is the body's blueprint to cure itself and to stay young, only works "on a substrate of calcium'. Thus the DNA will only repair the body when the body fluids are full of calcium and therefore alkaline. This is why many diseases are considered to be incurable, as without nutrition, the body remains acidic and DNA replication is inhibited.
So then, what are the nutrients that the body need to cure itself The answer begins with calcium. There is no such thing as a bad calcium nutrient. All calcium nutrients are good for producing a healthy body; however, some are better than others. For example, the consumption of coral calcium provides adequate calcium, magnesium and dozens of trace minerals for absorption by the body. Some calcium nutrients, such as calcium carbonate, are difficult for the body to absorb. This does not mean that they are not good, but rather that there are better choices. Also, there is no such thing as a bad coral calcium from Okinawa. They are all miracle minerals. However, some are better than others. The Japanese grade the coral based on magnesium content. The more magnesium a coral has, the higher it is graded. Consuming coral calcium can be classified in the same category as breathing as both fill the body with life sustaining oxygen. Most suppliers of coral calcium instruct you to take 2 to 3 capsules each day. But this is for maintaining good health. When you are sick, it is best to double-up to 4 to 6 per day. If you are really sick, with a disease such as cancer, Lupus, diabetes, etc., it is best to triple-up to 6 to 9 per day. The author has been told by many that a few months on the larger dose coral has successfully terminated their cancer, Lupus, Multiple Sclerosis and numerous other incurable diseases. Of course all of these people exposed themselves to sunshine and a host of other nutrients as well as the coral calcium.
Of course, other nutrients are also required, the most important being exposure to sunshine. Sun on the skin produces inisotol triphospate to regulate mineral disposition in the body and it also produces vitamin-D which allow the intestine to absorb large amounts of nutrients. The ultraviolet radiation from the sun striking the eyes stimulate the pituitary, pineal and hypothymus glands at the back of the eye to regulate the production of many hormones such as melatonin, seritonin and calcium-regulating calcitonin. Thus lack of sunshine on the body is responsible for a host of diseases, especially cancer. This sounds like a controversial statement, but not when you look at the facts. 'Me cancer-free black African is naked in the sun all day while the black American who avoids the sun like the plague, has three times the cancer rate of the sun worshipping white Americans. There is twice as much breast cancer in the Northern States as in the sunny Southern States. Prostate cancer goes up almost 300% from the sunny Mexican border to the Northern Canadian border. When exposure to the sun does trigger skin cancer, the victim is usually a white albino who already has five other mineral deficiency induced diseases, and is well on the way to developing the sixth.
Other important nutrient sources are multi-vitamins, which can be purchased inexpensively in all major stores. The instructions on the bottle may say to take one each day; however, the many cultures around the world that never get sick take about 100 times the amounts that is recommended in America. This means that you should take several every day, the author recommends at least 6 per day, as by the millions, these people have proven that there is no such thing as too much when it comes to vitamins and minerals. There is however, one exception, and that is large amounts of liquid calcium that can lead to hypercalcemia, if the body is not exposed to sunlight for at least. one hour each day. Large quantities of coral calcium do not require sunshine as no amount of coral calcium can cause hypercalcemia. Also, trace minerals can be found in most health stores. Once again the instructions will say one per day, but 6 per day is recommended. Vitamin-D is also necessary to insure the absorption of nutrients. A minimum of 5000 IU is suggested. Extra boron, selenium, chromium, zinc, vitamin-A, vitamin-E and cesium is also recommended.
Although almost all degenerative diseases can be prevented and cured nutritionally if given enough time, people are always asking, "What can I do if I am terminal ?" A terminal cancer patient, for example, may be cured over a 6 month period by consuming the proper nutrients, but may only have 3 weeks to live. This situation requires a more potent nutrient treatment. A combination of common mineral salts can penetrate the tumor and then react to create concentrated and corrosive sulfuric acid which then kills the tumor. Also, cesium chloride, a natural salt, and where it is found, cancer does not exist, can quickly alkalize and thereby terminate the cancer. Cesium is the most caustic mineral that exists, and when it enters the body, it seeks out all of the acidic cancer hotspots, dousing the fire of cancer, thereby terminating the cancer within days. Also, when dimethyl sulfoxide (DMSO) is rubbed near a painful cancer, the pain is removed and the DMSO causes the cesium to penetrate the cancer tumor much faster, thereby terminating the cancer much faster. DMSO is an approved drug in 125 countries around the world and 600 million people have used it therapeutically. Larger doses of vitamin-D will cause the body to alkalize faster bringing a speedy end to the cancer. Otto Warburg's oxygen respiration enzyme formula (Oxy-Plus, 520-684-4458) has also been proven to be effective against cancer.
Dr Karl Folker discovered CoQ IO in the 1960s while working for the giant pharmaceutical company Merck. He found it to eliminate cancer tumors in the breast, lung and stomach, Biochemical and Biophysical Research Communications, March 30, 1994. And finally, gold metal absorbed by the body has been found effective in recovering from cancer.
The following program has been found to be effective for cancer: 1. Consume 6 coral calcium capsules each day, 2 in morning, 2 in afternoon and 2 at night. 2. Consume 150 grams of mineral salts (5 per day) and then consume I 00 grains of cesium chloride at 3 grams each day (one gram morning, noon and night, total 33 days). 3. Consume 100 milligrams of CoQ IO each day for 30 days. 4. Consume one Oxy-Plus (500 mg) three times each day. 5. Apply DMSO gel to skin nearest the cancer (or nearest to pain) twice a day. 6. Apply gold gel to skin nearest the cancer once each day. 7. Consume 6 vitamin-D tablets (5000 JU) each day, 2 in the morning, 2 in the afternoon and 2 at night. 8. Eat two bananas, and/or two large potatoes, two glasses of milk or two glasses of orange juice and eat raisons, tomatoes, spinach or broccoli every day (all contain lots of potassium, magnesium and calcium).
Expose your skin and face to a least two hours of sunshine every day with no skin block and no glasses (allows for the production of inositol triphosphate, calcitonin and vitamin D to help regulate crucial minerals such as calcium). Sun exposure is mandatory, even with s@ cancer. Note:
1. All of the above ingredients are available at 520-684-4458. 2. This program will help to alkalize the body's fluids, resulting in the toxins, which are adhered to the cell surface, detaching themselves and entering the blood. The body will recognize the toxins as foreign invaders and respond by attacking them possibly causing flu-like symptoms like headaches, stomach aches and diarrhea. This is called "detoxing" and it means that the body is ridding itself of cancer inducing compounds.
After the cesium has been consumed (33 days) the cancer will be benign (only a biopsy can prove this). Continue taking all of the other nutrients except for the DMSO which should only be used for pain control.
The author has witnessed numerous people with terminal cancers who have employed the above program successfully. In the author's web site (www.cureamerica.net), and in the Testimonials section of this book, numerous testimonials are provided by prestigious Americans. The author has also witnessed hundreds of other less prestigious Americans cure their incurable diseases. Although their testimony is considered hearsay and unscientific, examining their medical records, which state that they are all terminal, and then matching them to the now healthy bodies, is very exciting. Pancreatic cancer for example is a death sentence. When a tearful Ray explained that his mother was only given less that 3 months to live due to a metastasized pancreatic cancer, he readily defied his doctors and put her on the cesium program. That was 3 years ago and his mother recently remarried and is currently on her second honeymoon. A young lady in Oklahoma with metastasized cancer was scheduled for a double mastectomy and colonescopy prior to undertaking the cesium program. Today she is ecstatic as she has both breasts and her rectum is intact.
Alkalizing the body with nutrition allows the body to cure itself, even from previously incurable diseases. Nobel Prize winner, Otto Warburg complained in 1966 that because the agnostics were in control, millions of men and women would have to die needlessly from cancer. Today the agnostics are still in control, but their control has weakened substantially, due to information exchange by computers and the interact. Warburg was right as millions of Americans did die. The time is ripe to end the needless suffering, pain and death caused by curable degeneration diseases such as cancer and heart disease. The time has come to cure America.